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内容简介
“精要速览系列(InstantNotesSeries)”丛书是国外教材“BestSeller”榜的上榜教材。该系列结构新颖，视角独特；重点明确，脉络分明；图表简明清晰；英文自然易懂，被国内多所重点院校选用作为双语教材。先锋版是继“现代生物学精要速览”之后推出的跨学科的升级版本。
本书是该系列中的《医药化学》分册，全书共13章，综合了化学、生物学和计算机科学的内容，扼要介绍了药物设计与发现、新药开发与应用、临床试验及专利申请等。
本书是指导大学生快速掌握医药化学基础知识的优秀教材，也是辅助教师授课的极佳教学参考书，同时可供相关专业的研究生参考。
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顾客评论
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目录
Abbreviations
Preface
About the author
Section A-The science of medicinal chemistry
A1 Introduction
A2 From concept to market
Section B-Drug targets
B1 Enzymes
B2 Receptors
B3 Carrier proteins
B4 Structural proteins
B5 Nucleic acids
B6 Lipids
B7 Carbohydrates
Section C-Pharmacokinetics
C1 Pharmacokinetics
C2 Drug absorption
C3 Drug distribution
C4 Drug metabolism
C5 Drug excretion
C6 Drug administration
C7 Drug dosing
Section D-Biological testing and bioassays
D1 Testing drugs
D2 Testing drugs in uitro
D3 Testing drugs in uiuo
Section E-Drug discovery
E1 The lead compound
E2 Natural sources of lead compounds
E3 Synthetic sources of lead compounds
Section F-Synthesis
F1 Synthetic considerations
F2 Stereochemistry
F3 Combinatorial synthesis
Section G-Structure-activity relationships
G1 Definition of structure-activity relationshiips
G2 Binding interactions
G3 Functional groups as binding groups
G4 The pharmacophore
G5 Quantitative structure-activity relationships
Section H-Target orientated drug design
H1 Aims of drug design
H2 Computer aided drug design
H3 Simplification of complex molecules
H4 Conformational restraint
H5 Extra binding interactions
H6 Enhancing existing binding interactions
Section I-Pharmacokinetic orientated drug design
I1 Drug solubility
I2 Drug stability
Section J-Patenting and manufacture
J1 Patenting and chemical development
J2 Optimization of reactions
J3 Scale-up issues
J4 Process development
J5 Specifications
Section K-Preclinical testing and clinical trials
K1 Toxicology
K2 Pharmacology and pharamceutical chemistry
K3 Drug metabolism studies
K4 Clinical trials
K5 Regulatory affairs
Section L-Case study:inhibitors of EGF-receptor kinase
L1 Epidermal growth factor receptor
L2 Testing procedures
L3 From lead compound to dianilino-phthalimides
L4 Modeling studies
L5 4-(Phenylamino)pyrrolopyrimidines
L6 Pyrazolopyrimidines
Section M-History of medicinal chemistry
M1 The age of herbs,potions and magic
M2 The nineteenth century
M3 A fledgling science(19-193)
M4 The dawn of the antibacterial age(193-1945)
M5 The antibiotic age(1945-197s)
M6 The age of reason (197s to present)
Further reading
Index
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